Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC TL033 TFA | 2746343-70-2 | 98.1% | 1630.83 | 5 MG
TL033 TFA (HY-147340A) is a chemical compound with CAS number 2746343-70-2 and a molecular weight of 1630.83. This product is supplied as a light yellow to yellow solid with a high purity of 98.1% (HPLC). It requires specific storage conditions to maintain its integrity, ensuring reliability for research applications.
- CAS number: 2746343-70-2
- Purity (HPLC): 98.1%
- Molecular weight: 1630.83
- Appearance: Light yellow to yellow solid
- Recommended storage (solid): -20°C, sealed, away from moisture and light
- Storage in solvent: -80°C (6 months) or -20°C (1 month), sealed, away from moisture and light
![Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.9% | 1323.35 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386801-logo.png-250.jpg){kind=logo}
Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.9% | 1323.35 | 1 MG
OncoACP3 TFA from MedChemExpress is a small-molecule ligand of prostatic acid phosphatase (ACP3). This product is applicable to research related to prostate cancer.
- Molecular formula: C62H82F3N12O15P
- Molecular weight: 1323.35
- Appearance: White to off-white solid
- Storage: Powder at -20°C for 3 years; in solvent at -80°C for 6 months, or -20°C for 1 month
- Purity (LCMS): 99.87%
Medchemexpress LLC GRGDSP TFA | 98.0% | 701.61 | 25 MG
GRGDSP (TFA) is an integrin inhibitor. This synthetic linear RGD peptide can inhibit the adherence of tumor cells to endothelial cells of blood vessels, thereby limiting metastasis. It is also utilized to modify the surface of cardiovascular implants, such as vascular grafts, to promote endothelialization, and is widely employed in integrin research as a soluble integrin-blocking RGD-based peptide.
- Inhibits adherence of tumor cells to endothelial cells of blood vessels
- Limits metastasis
- Promotes endothelialization for cardiovascular implants
- Used in integrin research
- Functions as a soluble integrin-blocking RGD-based peptide
Medchemexpress LLC Alpha-Melanocyte-Stimulating Hormone TFA | 171869-93-5 | 98.5% | 1 MG
α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) is an endogenous neuropeptide and a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities and is a post-translational derivative of pro-opiomelanocortin (POMC).
- Endogenous neuropeptide
- MC4R agonist with anti-inflammatory and antipyretic activities
- Post-translational derivative of pro-opiomelanocortin (POMC)
- Modulates CNS inflammation by acting directly on melanocortin receptors in glial cells
- Modulates NFκB activation
- Inhibits translocation of transcription factor κB to the nucleus
Medchemexpress LLC Vh4127 TFA | 1034.35 (free base) | 1 MG
VH4127 TFA is a cyclic peptide that targets the low-density lipoprotein receptor (LDLR) with a KD of 18 nM for hLDLR. It specifically binds to the epidermal growth factor (EGF) homology domain of both rodent and human LDLR.
- Targets low density lipoprotein receptor (LDLR)
- Has a high binding affinity (KD of 18 nM) for human LDLR
- Binds specifically to the EGF homology domain of rodent and human LDLR
- Available in various quantities
- For research use only
- Information on solubility, in vivo dissolution, and related antibodies is also available
Medchemexpress LLC Katacalcin TFA | 99.6% | 2550.62 | 25 MG
Katacalcin TFA (PDN 21 TFA) is a potent plasma calcium-lowering peptide from the calcitonin family. It rapidly decreases blood calcium and phosphate by promoting their incorporation into bones. It also deactivates CD14+ peripheral blood mononuclear cell (PBMC) chemotaxis and regulates their migration.
- Potent plasma calcium-lowering peptide
- Belongs to the calcitonin family
- Promotes incorporation of calcium and phosphate into bones
- More potent inhibitor of fMLP-induced chemotaxis
- Deactivates CD14+ peripheral blood mononuclear cell (PBMC) chemotaxis
- Regulates human CD14+ PBMC migration
Medchemexpress LLC Tfllr-nh2(tfa) | 1313730-19-6 | 99.6% | 761.83 | 5 MG
TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM, intended for research use only. It appears as a white to off-white solid.
- Acts as a selective PAR1 agonist
- Stimulates concentration-dependent increases in [Ca2+]i in neurons
- Activated platelets upregulate E-cadherin and downregulate vimentin expression in SW620 cells
- Increases secreted TGF-β1 in platelet cultures
- Injection into rat paws stimulates marked and sustained oedema
- Stimulates Evans blue extravasation in various organs in wild-type mice
- Can induce both contraction and relaxation in rat duodenal smooth muscle
- Recommended storage for powder is -80°C for 2 years or -20°C for 1 year
- Recommended storage in solvent is -80°C for 6 months or -20°C for 1 month
- High solubility in DMSO and H2O (100 mg/mL)
Medchemexpress LLC CPP9 TFA | 99.9% | 1553.37 | 1 MG
CPP9 TFA is a small, amphipathic, cyclic cell penetrating peptide (CPP). CPPs bind directly to the plasma membrane phospholipids and enter mammalian cells via endocytosis, followed by efficient release from the endosome. It can be used for intracellular delivery of therapeutic agents and chemical probes.
- Small, amphipathic, cyclic cell penetrating peptide
- Binds directly to plasma membrane phospholipids
- Enters mammalian cells via endocytosis
- Efficient release from the endosome
- Used for intracellular delivery of therapeutic agents
- Used for intracellular delivery of chemical probes
Medchemexpress LLC DV1 TFA | 98.53% | 2424.85 | 25 MG
DV1 TFA is a selective antagonist for CXC chemokine receptor 4 (CXCR4). It exhibits antiviral activity by blocking HIV-1 entry through the CXCR4 co-receptor, making it suitable for research applications.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- Blocks HIV-1 entry
Medchemexpress LLC Cys-PKHB1 TFA | 1487.88 | 25 MG
Cys-PKHB1 TFA is a peptide conjugated to PKHB1, a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects.
- Induces mitochondrial alterations
- ROS generation
- Intracellular Ca+ accumulation
- Calcium-dependent cell death in breast cancer cells
- Induces immune system activation in breast cancer cells through immunogenic cell death
Medchemexpress LLC Reltecimod TFA | 1447799-33-8 | ≥98% | 1037.19 | 25 MG
Reltecimod TFA is a T cell-specific surface glycoprotein CD28 (TP44) antagonist. It demonstrates good resistance to various bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 costimulatory pathway without inhibiting it. It may be used to study necrotizing soft tissue infections (NSTIs).
- T cell-specific surface glycoprotein CD28 (TP44) antagonist
- Good resistance to different bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation
- Modulates inflammatory response by attenuating the CD28/B7-2 costimulatory pathway
- May be utilized to study necrotizing soft tissue infections (NSTIs)
- Increases survival rate of mice harboring several bacterial infections (at 1.25-5 mg/kg; iv)
Medchemexpress LLC Ribupatide (TFA) | 2940971-65-1 | >91.6% | 4907.523 | 25 MG
Ribupatide (TFA) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist, suitable for various laboratory research applications. This synthetic peptide is often studied in antidiabetic research and related metabolic disease areas.
- Dual GIP/GLP-1 receptor agonist
- Ideal for antidiabetic research
- High purity for reliable results
- Synthetic peptide for consistent quality
- Suitable for various laboratory applications