Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
eMolecules 76-05-1 | Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100g | 537709016
Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100g | 537709016
Medchemexpress LLC LL-37 amide TFA | 597562-32-8 | 99.3% | 4492.28 (free base) | 1 MG
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1. It inhibits periodontal pathogens and exerts bactericidal effects by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It also regulates inflammatory responses by inhibiting factors like TNF-α and promotes angiogenesis. Amidation enhances its stability and reduces serum inhibition, making it useful in research for infection-related diseases, periodontal disease, deep tissue injuries, and wound healing.
- Improved stability and resistance to enzymatic degradation.
- Exhibits broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria.
- Accelerates wound healing and bacterial clearance in Staphylococcus aureus skin infection models.
- Safe concentration range for eukaryotic cells is 0.1-10 μM.
Medchemexpress LLC APL180 TFA | 98.8% | 2310.60 (free base) | 5 MG
APL180 TFA (L-4F) is an apolipoprotein AI mimetic peptide. It enhances the anti-inflammatory activity of high-density lipoprotein (HDL) and is utilized in the study of cardiovascular diseases.
- Enhances anti-inflammatory activity of high-density lipoprotein (HDL)
- Useful in cardiovascular disease research
- Purity: 98.8%
- Molecular weight: 2310.60 (free base)
- Soluble in DMSO and various in vivo dissolution protocols
Medchemexpress LLC GIP, rat TFA | 99.8% | 5002.58 | 5 MG
GIP, rat TFA is a bioactive peptide of rat origin, also known as glucose-dependent insulinotropic polypeptide or gastric inhibitory polypeptide. This 42-amino acid peptide is released by K cells in the duodenum and jejunum in response to food intake. GIP, along with GLP, stimulates insulin secretion from pancreatic beta cells and appears to promote beta cell proliferation and survival. Recent studies suggest a role for GIP in lipid homeostasis and a potential function in the pathogenesis of obesity.
- Bioactive peptide of rat origin
- 42-amino acid peptide
- Released by K cells in duodenum and jejunum
- Stimulates insulin secretion from pancreatic beta cells
- Promotes beta cell proliferation and survival
- Plays a role in lipid homeostasis
Medchemexpress LLC DOTA-LM3 TFA | 99.3% | 1664.18 | 5 MG
DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist. The LM3 component refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, which is also a somatostatin antagonist. This product is often isotopically labeled for in vivo tumor tracing, such as 177Lu-DOTA-LM3 TFA and 68Ga-DOTA-LM3 TFA. It can be used for the synthesis and research of Radionuclide-Drug Conjugates (RDCs).
- Acts as an antagonist for somatostatin receptors
- Commonly labeled with isotopes like 177Lu or 68Ga for in vivo tumor tracing
- 68Ga-DOTA-LM3 TFA exhibits favorable biodistribution
- Shows high tumor uptake and good tumor retention
- 68Ga-DOTA-LM3 TFA has few safety concerns
- Useful for research in DOTATOC-negative liver metastases, including pancreatic NET and extensive tumor thrombosis
- Can be utilized for the synthesis and research of Radionuclide-Drug Conjugates (RDCs)
Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 (free base) | 25 MG
[D-Lys6]-LH-RH TFA is a Luteinizing-hormone-releasing hormone (LHRH) analogue. It acts as a GnRH receptor agonist.
- Luteinizing-hormone-releasing hormone (LHRH) analogue
- GnRH receptor agonist
Medchemexpress LLC Alvespimycin (17-DMAG) trifluoroacetate | 00-00-0 | MFCD08457919 | 99.0% | 730.77 g/mol | C34H49F3N4O10 | 5 MG
Alvespimycin TFA is the trifluoroacetate salt of 17-DMAG, a small-molecule inhibitor of heat shock protein 90 (Hsp90) used as a research reagent to study Hsp90-dependent signaling and anticancer mechanisms. The compound binds Hsp90 with an EC50 of 62 nM and is supplied as a high-purity, pale purple solid for laboratory use.
- Potent Hsp90 inhibitor (EC50 62 nM).
- Trifluoroacetate (TFA) salt form for consistent handling.
- High purity (reported ~98.97%).
- Molecular weight 730.77 g/mol.
- Pale purple solid appearance.
- Storage: sealed, away from moisture and light; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Vm24-toxin TFA | 1373890-79-9 | 3863.59 | 5 MG
Vm24-toxin is a 36-residue peptide that acts as a potent and selective Kv1.3 blocker with a Kd of approximately 3 pM in lymphocytes. It exhibits over 1500-fold affinity for Kv1.3 compared to other tested potassium channels. This toxin attenuates the CD4+ effector memory T cell response to T cell receptor (TCR) stimulation.
- Potent and selective Kv1.3 blocker
- Exhibits over 1500-fold affinity for Kv1.3
- Attenuates CD4+ effector memory T cell response
Medchemexpress LLC PBX-7011 TFA | 98.6% | 561.46 | 5 MG
PBX-7011 TFA is a derivative of camptothecin. It inhibits expressions of the cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP in FaDu cells, degrades DDX5 proteins, and exhibits anticancer activity.
- Inhibits expressions of cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP in FaDu cells.
- Degrades DDX5 proteins.
- Exhibits anticancer activity.
Medchemexpress LLC KRpep-2d TFA | 2098181-84-9 | 95.1% | 2675.03 | 2 MG
KRpep-2d is a potent inhibitor of K-Ras, designed to impede the proliferation of K-Ras-driven cancer cells. It is suitable for use in cancer research. The product possesses a cyclic structure, which is crucial for its K-Ras inhibitory activity, with specific amino acid residues (Leu77, Ile9, and Asp12) being critical for this function.
- Potently inhibits K-Ras activity.
- Reduces the proliferation of cancer cells driven by K-Ras.
- Features a cyclic structure important for its inhibitory action.
- Critical amino acid residues contribute to its effectiveness.
- Can be used for cancer research applications.
Medchemexpress LLC Ac-VEID-CHO (trifluoroacetate salt) | 00-00-0 | 99.8% | 614.57 Da | C24H37F3N4O11 | 1 MG
Ac-VEID-CHO (TFA) is a peptide-derived reversible caspase inhibitor intended for in vitro research into apoptosis and neurodegenerative pathways. It is supplied as a trifluoroacetate salt and demonstrates potent inhibition of several executioner caspases in biochemical assays. Not for human or clinical use.
- Reversible caspase inhibitor targeting caspase-6, caspase-3, and caspase-7.
- Reported IC50 values in the low nanomolar range for primary targets.
- High purity suitable for biochemical assays (99.8%).
- Available in small mg-scale quantities for research use.
- Limited cellular activity due to poor cellular accumulation.
Medchemexpress LLC Bibo3304 | 191868-14-1 | 100.0% | 643.66 | C31H36F3N7O5 | 25 MG
BIBO3304 is a potent, selective neuropeptide Y (NPY) Y1 receptor antagonist used as a research probe. It exhibits subnanomolar affinity at human and rat Y1 receptors (IC50 = 0.38 nM and 0.72 nM) and is supplied in solid and solution formats with high reported purity.
- High potency with subnanomolar IC50 values for human and rat Y1 receptors.
- High reported purity (99.96%).
- Available as solid and as a 10 mM DMSO solution for assay readiness.
- Molecular formula C31H36F3N7O5 and molecular weight 643.66 g/mol.
- Suitable for receptor pharmacology and in vitro pharmacodynamic studies.
Medchemexpress LLC 3x DYKDDDDK Tag (TFA) | 98.17% | 3116.90 | 5 MG
DYKDDDDK peptide (FLAG) is a useful tool for investigating the function and localization of proteins when antibodies are not available. It is often used in a 3X FLAG format for purifying difficult proteins that accumulate in low abundance.
- Useful tool for investigating protein function and localization
- Often used in 3X FLAG format for purifying difficult proteins
- Suitable for proteins that accumulate in low abundance